International Journal of Pharmaceutical Science and Health Care Issue 3, Vol 6. December 2013 Available online on http://www.rspublication.com/ijphc/index.html ISSN 2249 – 5738

BCS class II drugs associated as they are with low aqueous solubility and bioavailability pose an alarming challenge for the pharmaceutical scientists from the point of view of formulation by conventional methods. That is all the more surprising as around forty percent of the new generated drugs exhibit poor water solubility. However , the formulation of such drugs is now being increasingly done through the latest technique of nanosuspension formulation . Among the major advantages of this technique is the fact that nanosuspensions can be formulated for various routes of administration like oral, parenteral, ocular, and pulmonary and targeted drug delivery system. Nanosuspension technology increases the dissolution velocity, saturation solubility, adhesion, and bioavailability that lead to a decrease in the dose and fast-fed variability thereby playing a vital role in drug discovery. Nanosuspensions help in administering huge drug concentration of the poorly water soluble drugs to brain with decreased systemic effects. In fact, nanosuspension technology achieves that target by altering the pharmacokinetics of the drug and improves drug safety and efficacy.